Installing an APK file.
set up your virtual device
click on the Apps tab and use the Install button to load your APK file
See what a program does to the system
if your program is just a command-line executable, use the Files tab to open file browser and install it somewhere on the filesystem, then use the Console (type su for root privileges) to make it executable. Otherwise, the app should show up in the app list and you can use the Launch button to start it; you should also see it in the Launcher.
use CoreTrace to capture system calls made by your program
Debug the app
you should be able to attach to your app's process in the Frida tab
if you want to use Android debug tools, connect to the VPN
after your VPN is working, you can connect to the ADB (Android Debug Bridge) - see Connect tab
Automatically install and run your app
download the Corellium node.js API: https://github.com/corellium/corellium-api
read the README file for more useful tools (for instance checking if app is already installed and uninstalling it, as well as retrieving log files - if your app writes one)